Ohio River Valley Vacations from $302

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Your Ohio River Valley Vacation

Plan the adventure you've always wished for with a tailor-made Ohio River Valley vacation package. Get set to experience culture, history and plenty of other highlights in this unique destination. Your trip to Ohio River Valley wouldn't be complete without exploring some of its best cities, starting with Indianapolis. Some of the top attractions here include Lucas Oil Stadium and Indianapolis Motor Speedway. Columbus is another favorite with Ohio River Valley travelers. Visitors to this exciting destination enjoy Easton Town Center and COSI. From the instant you book your Ohio River Valley vacation to the second you come back home, Expedia will be with you every step of the way.

The Latest Ohio River Valley vacation packages

Price found within the past 48 hours. Click for updated prices.
Hampton Inn Chicago-Carol Stream
Hyatt Regency Cincinnati
Hilton Chicago/Oak Lawn
Hilton Cincinnati Netherland Plaza
Staybridge Suites, Lincolnshire by IHG
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Where to stay in Ohio River Valley

Find the best Ohio River Valley areas and neighborhoods for the activities you enjoy most. Learn more about Ohio River Valley

Discover the most popular places to visit in Ohio River Valley

Ohio River Valley Hotel Deals

Hyatt Regency Cincinnati

Hyatt Regency Cincinnati

4 out of 5
151 West Fifth Street, Cincinnati, OH
Fully refundableReserve now, pay when you stay
$141 nightly
The price is $168 total per night from Sep 1 to Sep 2
$168 total
Sep 1 - Sep 2
Total includes taxes and fees
8.8/10 Excellent! (1,485 reviews)
"I liked that it was surrounded by walkable shopping and dining options."

Reviewed on Aug 11, 2025

Hyatt Regency Cincinnati
Crowne Plaza Louisville Airport Expo Ctr by IHG

Crowne Plaza Louisville Airport Expo Ctr by IHG

3.5 out of 5
830 Phillips Lane, Louisville, KY
Fully refundable
$111 nightly
The price is $131 total per night from Aug 24 to Aug 25
$131 total
Aug 24 - Aug 25
Total includes taxes and fees
8.6/10 Excellent! (733 reviews)
"Outdoor pool was the best. My kids enjoyed. The staff at Al's? They were so nice to my kids and everyone was very pleasant"

Reviewed on Aug 10, 2025

Crowne Plaza Louisville Airport Expo Ctr by IHG
Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham

4 out of 5
140 North Fourth Street, Louisville, KY
Fully refundableReserve now, pay when you stay
$129 nightly
The price is $151 total per night from Aug 31 to Sep 1
$151 total
Aug 31 - Sep 1
Total includes taxes and fees
8.8/10 Excellent! (3,510 reviews)
"They seem to be updating rooms, mine was pristine. Clean hotel all around. 0 signs of mold or bugs as other reviewers have mentioned. Room service was at my door within 15 minutes of ordering. Friendly staff. Great time all around."

Reviewed on Aug 11, 2025

Galt House Hotel Trademark Collection by Wyndham
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.